Staying Hydrated While Taking GLP-1s

Do GLP-1 medications affect hydration?

Thirst isn’t always a reliable way to tell if you are drinking enough liquids when using GLP-1s. That’s because GLP-1s may reduce your thirst and cause gastrointestinal (GI) side effects that may affect your body’s fluid balance.

Also, some common side effects can influence your hydration levels. They include:

• nausea
• vomiting
• diarrhea

Typically, you will feel fuller faster and have a reduced appetite with using GLP-1 medication, which can also lead to drinking fewer liquids. These effects can lower your overall fluid intake or lead to dehydration.

Signs of dehydration

The following are signs of dehydration to be aware of that suggest you may need more fluids:

• dark or concentrated urine
• dry mouth
• headache
• dizziness or lightheadedness
• worsening constipation
• unexplained fatigue

When to seek medical care

Contact your doctor or healthcare team if you experience severe or persistent vomiting or diarrhea (lasting more than 24 hours), significantly decreased urination, confusion, or signs of dehydration that don’t improve.

How much water do you need on GLP-1s

The amount of water a person needs each day varies based on factors such as age, activity level, and overall health. The Academy of Nutrition and Dietetics suggests the following general guidelines in adults:

• 11.5 cups of water per day for women
• 15.5 cups of water per day for men

Nonalcoholic drinks and fresh fruits and vegetables can also count towards your overall fluid intake. However, you may wish to discuss your individual fluid needs with your healthcare professional to ensure you are getting enough.

Hydration strategies when using GLP-1s

Staying hydrated is crucial when taking GLP-1 medications, as they can significantly reduce thirst and slow digestion. The following strategies can help ensure you are getting adequate fluids to stay hydrated throughout the day.

Create a sipping schedule

To increase your intake of fluids consider:

• setting reminders or using a measured bottle
• front-loading fluids earlier in the day if nighttime urination is an issue
• tracking intake visually. Typically, pale urine color means you are adequately hydrated, while dark urine indicates you need to drink more.
• using phone alarms or apps reminding you to drink water

Manage nausea

If nausea makes water or other fluids hard to tolerate, consider:

• taking small, frequent sips throughout the day
• drinking water in various forms, such as cold water, ice chips, or flavored water without added sugar
• trying clear broths or herbal teas, such as ginger or peppermint

Address vomiting or diarrhea

If you are experiencing bothersome vomiting and diarrhea, try:

• using oral rehydration options, such as electrolytes
• contacting your healthcare professional if symptoms are severe or persistent

Note: Do not “push through” severe symptoms. Your healthcare professional can recommend ways to help you manage severe vomiting or diarrhea, as well as look for other potential causes.

What to drink on GLP-1 medications

• water
• sparkling water
• unsweetened beverages
• herbal teas
• electrolyte drinks if you are vomiting or have diarrhea

Takeaway

GLP-1s may reduce thirst and increase your risk of dehydration, especially if you are experiencing certain GI side effects. Hydration strategies, such as sipping water throughout the day and maintaining a regular schedule, can go a long way toward helping you stay hydrated. If you have questions about how much liquid you should drink, talk with your doctor for individualized recommendations.