Rystiggo (rozanolixizumab-noli) is a prescription drug that’s used to treat myasthenia gravis. This drug can interact with certain other medications. For example, Rystiggo can interact with monoclonal antibodies and immunoglobulins.
Rystiggo is used in certain adults to treat generalized myasthenia gravis.
Rystiggo contains the active ingredient rozanolixizumab-noli. The reason “-noli” appears at the end of the drug’s name is to show that the drug is distinct from similar medications that may be created in the future.
Rystiggo is given as an injection under the skin over a period of time by your doctor or another healthcare professional.
An interaction can occur because one substance causes another substance to have a different effect than expected. Interactions can also occur if you have certain health conditions.
Keep reading to learn about Rystiggo’s possible interactions. For a detailed overview of this drug, check out this in-depth Rystiggo article.
Before you receive Rystiggo, tell your doctor and pharmacist about any prescription, over-the-counter, or other drugs you take. Sharing this information with them may help prevent possible interactions. (To learn whether Rystiggo interacts with herbs, vitamins, or supplements, see the “Are there other interactions with Rystiggo?” section.)
If you have questions about drug interactions that may affect you, talk with your doctor or pharmacist.
The table below lists drugs that may interact with Rystiggo. Keep in mind that this table does not include all drugs that may interact with Rystiggo. For more information about some of these interactions, see the “Drug interactions explained” section.
| Drug group or drug name | Drug examples | What can happen |
| monoclonal antibodies | • belimumab (Benlysta) • eculizumab (Soliris) • secukinumab (Cosentyx) • rituximab (Rituxan) | can make the monoclonal antibody less effective |
| biologics that contain modified antibodies | • abatacept (Orencia) • etanercept (Enbrel) • rilonacept (Arcalyst) | can make the biologic less effective |
| immunoglobulins | • hepatitis B immune globulin (Hepagam B, others) • intravenous immunoglobulin (IVIG) (Octagam, others) • rabies immune globulin (Imogam, others) • varicella zoster immune globulin (Varizig) | can make the immunoglobulin less effective |
Rystiggo is not known to interact with alcohol. But Rystiggo and alcohol can cause some similar side effects, such as headache and nausea. So you may be more likely to experience these side effects if you drink alcohol during your Rystiggo treatment.
If you have questions about consuming alcohol during your Rystiggo treatment, talk with your doctor or pharmacist.
Learn more about certain drug interactions that can occur with Rystiggo.
Interaction with monoclonal antibodies
Rystiggo can interact with monoclonal antibodies, which are lab-made antibodies that are used for many different conditions. These include certain cancers, inflammatory conditions, and autoimmune diseases, such as rheumatoid arthritis and psoriasis.
Examples of monoclonal antibody medications include:
- belimumab (Benlysta)
- eculizumab (Soliris)
- rituximab (Rituxan)
- secukinumab (Cosentyx)
What could happen
Combining Rystiggo with a monoclonal antibody can lower the level of the monoclonal antibody in your system. This can make the monoclonal antibody less effective.
What you can do
If you’re prescribed Rystiggo with a monoclonal antibody, your doctor will monitor you closely during your treatment to ensure the monoclonal antibody is working effectively.
However, if you have a condition that requires long-term treatment with a monoclonal antibody, your doctor likely will not prescribe Rystiggo for you. You can talk with your doctor about other medications that may be better options for your myasthenia gravis.
If you have questions about using Rystiggo with a monoclonal antibody, talk with your doctor or pharmacist.
Interaction with biologics that contain modified antibodies
Rystiggo is a biologic drug and can interact with other biologics that contain modified antibodies. (Biologics are drugs made in laboratories using living cells.)
Biologics that contain modified antibodies are used for certain inflammatory conditions and autoimmune diseases, such as rheumatoid arthritis and psoriasis.
Examples of biologic medications that contain modified antibodies include:
- abatacept (Orencia)
- etanercept (Enbrel)
- rilonacept (Arcalyst)
What could happen
Using Rystiggo with a biologic drug that contains modified antibodies can lower the level of the biologic drug in your body. This can make it less effective.
What you can do
If you combine Rystiggo with a biologic drug that contains modified antibodies, your doctor will monitor you closely during your treatment to make sure the biologic drug is still working for your condition.
But if you have a condition that needs long-term treatment with one of these biologics, your doctor likely will not prescribe Rystiggo for you. You can talk with your doctor about other medications that may be better options for your condition.
If you have questions about using these drugs together, talk with your doctor or pharmacist.
Interaction with immunoglobulins
Rystiggo can interact with immunoglobulins, which are blood products that contain antibodies (proteins that help protect your body from infection). They’re used to boost antibody levels in people with low levels.
Examples of immunoglobulins include:
- hepatitis B immune globulin (Hepagam B, others)
- intravenous immunoglobulin (IVIG) (Octagam, others)
- rabies immune globulin (Imogam, others)
- varicella zoster immune globulin (Varizig)
What could happen
Combining Rystiggo with an immunoglobulin can lower the level of the immunoglobulin in your body. This can make the immunoglobulin less effective.
What you can do
If you receive Rystiggo with an immunoglobulin, your doctor will monitor you closely during your treatment to make sure the immunoglobulin is working for you.
But if you have a condition that needs long-term treatment with an immunoglobulin, your doctor likely will not prescribe Rystiggo for you. You can talk with your doctor about other medications that may be better options for you.
If you have questions about using Rystiggo with immunoglobulins, talk with your doctor or pharmacist.
Rystiggo may have other interactions. They could occur with supplements, foods, vaccines, or even lab tests. See below for details. Note that this information does not include all other possible interactions with Rystiggo.
Does Rystiggo interact with supplements?
Before you start taking Rystiggo, talk with your doctor and pharmacist about any herbs, vitamins, or supplements you take. Sharing this information with them may help you avoid possible interactions.
If you have questions about interactions that may affect you, talk with your doctor or pharmacist.
Rystiggo and herbs
There are currently no reports of Rystiggo interacting with herbs. But this doesn’t mean that interactions with herbs won’t be recognized in the future.
For this reason, it’s still important to check with your doctor or pharmacist before taking any of these products while taking Rystiggo.
Rystiggo and vitamins
There are currently no reports of Rystiggo interacting with vitamins. But this doesn’t mean that vitamin interactions won’t be recognized in the future.
For this reason, it’s still important to check with your doctor or pharmacist before taking any of these products while taking Rystiggo.
Does Rystiggo interact with food?
There are currently no reports of Rystiggo interacting with food. If you have questions about eating certain foods during your treatment with Rystiggo, talk with your doctor.
Does Rystiggo interact with vaccines?
You should not receive live vaccines* during your Rystiggo treatment. This is because getting a live vaccine while you’re receiving Rystiggo increases your risk of infection. Examples of live vaccines include:
- measles, mumps, rubella (MMR)
- rotavirus
- chickenpox
- nasal spray flu vaccine (FluMist)
If you need to receive a vaccine, talk with your doctor first to make sure it’s safe.
* Live vaccines contain weakened versions of the bacteria or viruses that they’re meant to protect against.
Does Rystiggo interact with lab tests?
There are currently no reports of Rystiggo interacting with lab tests. If you have questions about having certain lab tests done during your treatment with Rystiggo, talk with the healthcare professional ordering the test.
Does Rystiggo interact with cannabis or CBD?There are currently no reports of Rystiggo interacting with cannabis (commonly called marijuana) or cannabis products such as cannabidiol (CBD). But as with any drug or supplement, talk with your doctor before using cannabis with Rystiggo.
Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.
Certain medical conditions or other health factors may raise the risk of interactions with Rystiggo. Before taking Rystiggo, talk with your doctor about your health history. They’ll determine whether Rystiggo is right for you.
Health conditions or other factors that might interact with Rystiggo include:
Infection: Rystiggo can raise your risk of infection. Before receiving Rystiggo, tell your doctor if you have an active infection or infections that keep coming back. (An infection is active if it’s currently causing symptoms). Your doctor may prescribe medication to treat the infection before you receive Rystiggo.
Pregnancy: It’s not known whether Rystiggo is safe to take during pregnancy. If you’re pregnant or planning a pregnancy, talk with your doctor before receiving Rystiggo.
Breastfeeding: It’s not known whether it’s safe to take Rystiggo while breastfeeding. It’s not known if the drug passes into breast milk or whether it may cause side effects in a child who’s breastfed. If you’re breastfeeding or planning to do so, talk with your doctor about your options.
Allergic reaction: If you’ve had an allergic reaction to Rystiggo or any of its ingredients, your doctor will likely not prescribe Rystiggo. This is because receiving the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better choices for you.
Taking certain steps can help you avoid interactions with Rystiggo. Before starting treatment, talk with your doctor and pharmacist. Things to discuss with them include:
- whether you drink alcohol or use cannabis
- other medications you take, as well as any vitamins, supplements, and herbs (they can also help you fill out a
medication list ) - what to do if you start taking a new drug during your Rystiggo treatment
It’s also important to understand Rystiggo’s
If you have trouble reading or understanding this information, your doctor or pharmacist can help.
Taking Rystiggo exactly as prescribed can also help prevent interactions.
Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.