You can take Rexulti (brexpiprazole) either in the morning or at night. Because this medication stays in your system for a long time, the best time is whatever time allows you to be the most consistent and manage potential side effects.
Clinical trials have shown no significant difference in the drug’s effectiveness based on the time of day it’s taken.
Rexulti has a long half-life (approximately 91 hours), meaning it stays in your bloodstream for several days. It typically takes about 10 to 12 days of daily use to reach a steady level in your system. Because of this, the drug provides continuous coverage regardless of whether you take your dose at 8:00 a.m. or 8:00 p.m.
The most important factor in timing your dose is how your body reacts to the medication. People often choose their schedule based on two common, yet opposite, side effects of Rexulti.
| If you experience… | Consider taking Rexulti… | Here’s why: |
|---|---|---|
| drowsiness or fatigue | in the evening | Taking it before bed may help you sleep through the worst of these effects. |
| insomnia or restlessness | in the morning | Taking it early helps prevent the drug from interfering with your ability to fall asleep at night. |
Note: Consistency is key. To maintain a steady level of the drug in your body, aim to take Rexulti within the same one-hour window each day.
Missing a dose can impact how well Rexulti manages the symptoms of your condition.
If you have difficulty remembering your daily dose, try these strategies:
- Habit stacking: Link your dose to a daily ritual, such as brushing your teeth or eating breakfast.
- Digital reminders: Use a dedicated medication tracking app or a simple daily alarm on your phone.
- Visual cues: Use a weekly pill organizer and keep it in a high-visibility area, like your nightstand or kitchen counter.
You should consult a healthcare professional before changing your dosing schedule of Rexulti. They can help you transition safely to a different time of day. They can also help ensure that any side effects you’re experiencing aren’t a sign that your dosage needs to be adjusted.
If you miss a dose, take it as soon as you remember. But if it’s almost time for your next one, skip the missed dose and return to your regular schedule. Never take two doses of Rexulti at once.
Disclaimer: While Healthline strives for factual, comprehensive, and current information, this article is not a substitute for a licensed healthcare professional’s expertise. Always consult a doctor before taking or discontinuing any medication. Drug information is subject to change and may not cover all uses, directions, precautions, warnings, interactions, reactions, or adverse effects. The lack of a warning does not guarantee a drug’s safety, effectiveness, or appropriateness for all patients or specific uses. Learn more about our approach to content integrity.